Reference
Shepard, B. D., & Pluznick, J. L. (2017). Saving the sweetness: Renal glucose handling in health and disease. American Journal of Physiology-Renal Physiology, 313(1), F55–F61. https://doi.org/10.1152/ajprenal.00046.2017
Info
FirstAuthor:: Shepard, Blythe D.
Author:: Pluznick, Jennifer L.
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Title:: Saving the sweetness: renal glucose handling in health and disease
Year:: 2017
Citekey:: ShepardPluznick_2017_SavingSweetnessRenal
itemType:: journalArticle
Journal:: American Journal of Physiology-Renal Physiology
Volume:: 313
Issue:: 1
Pages:: F55-F61
DOI:: 10.1152/ajprenal.00046.2017
Link
Abstract
Glucose homeostasis is highly controlled, and the function of the kidney plays an integral role in this process. The exquisite control of blood glucose relies, in part, on renal glucose filtration, renal glucose reabsorption, and renal gluconeogenesis. Particularly critical to maintaining glucose homeostasis is the renal reabsorption of glucose; with ~162 g of glucose filtered by the kidney per day, it is imperative that the kidney have the ability to efficiently reabsorb nearly 100% of this glucose back in the bloodstream. In this review, we focus on this central process, highlighting the renal transporters and regulators involved in both the physiology and pathophysiology of glucose reabsorption.