Reference
Liu, W. N., Yan, M., & Chan, A. M. (2017). A thirty-year quest for a role of R-Ras in cancer: From an oncogene to a multitasking GTPase. Cancer Letters, 403, 59–65. https://doi.org/10/ghtdb8
Info
FirstAuthor:: Liu, Wai Nam
Author:: Yan, Mingfei
Author:: Chan, Andrew M.
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Title:: A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase
Year:: 2017
Citekey:: LiuEtAl_2017_ThirtyyearQuestRole
itemType:: journalArticle
Journal:: Cancer Letters
Volume:: 403
Pages:: 59-65
DOI:: 10/ghtdb8
Link
Abstract
Since the identification of R-Ras, which is the first Ras-related GTPase isolated based on sequence similarity to the classical RAS oncogene, more than 160 members of the Ras superfamily of GTPases have been identified and classified into the Ras, Rho, Rap, Rab, Ran, Arf, Rheb, RGK, Rad, Rit, and Miro subfamilies. R-Ras belongs to the Ras subfamily of small G-proteins, which are frequently implicated in cell growth and differentiation. Although the roles of R-Ras in cellular transformation and integrin-mediated cell adhesion have been extensively studied, the physiological function of this enigmatic G-protein was only revealed when a mouse strain deficient in R-Ras was generated. In parallel, a plethora of research findings also linked R-Ras with processes including tumor angiogenesis, axon guidance, and immune cell trafficking. Several upstream factors that modulate R-Ras GTP-binding were identified including Notch, semaphorin, and chemokine C-C motif ligand 21. A review of our evolving understanding of the role of RRas in oncogenesis is timely, as this year marks the 30th anniversary of the publication describing the cloning of R-Ras.
Blue: Important conclusions
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Additionally, considerable efforts have been devoted to deciphering the pro-proliferative and pro-migratory role of R-Ras in various epithelial tumor types. However, evidence supporting a definitive role for R-Ras in human cancer remains elusive.
Green: Agree with the paper
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These Ras-related GTPases were grouped based on sequence similarities into 11 major subtypes in which members share similar biological properties.
Yellow: Interesting
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and classified into the Ras, Rho, Rap, Rab,
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rentiation. Although the roles of R-Ra
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Orange
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Therefore, a review of the key R-Ras research milestones from the past three decades and redefinition of the role of this GTPase in carcinogenesis is timely.
- no estoy de acuerdo con esto